OrbitLens Is it possible to generate the parts of a secret key separately (on different machines) and is it possible to sign a message separately, without reconstructing the secret key from parts?
Yes!
If you've followed what's going on in Bitcoin country, there's been a lot of talk recently about Schnorr signatures, and what you can do with them.. Ed25519 is basically a Schnorr signature scheme, so most of the things you read can be applied directly to Stellar.
Blockstream's MuSig is an n-of-n multisignature scheme, that takes n public keys, generates an new, joint public key, and provides a way to sign partial signatures, and aggregate them into a full signature, w/o anyone having access to anything more than their own private key.
This can be extended to n-of-m by using SSS.